Herron was born in Norman, Oklahoma to Dr. Jack and Susan Herron and graduated from Westmoore High School in Oklahoma City in 2000. Growing up playing a lot of sports, primarily dance and basketball, she was inspired by her Dad and Grandpa who both played at Oklahoma State University for the legendary coach Henry Iba. Her Mom was a swimmer. From an early age she had no fear of pushing herself to the extreme. At the age of the three, she almost drowned and was rescued by her Mom. Hearing stories from her Dad of practicing six hours without water or food, at the age of seven she would practice basketball in the heat of the summer until she'd black out. She went out for track in the 7th grade and fell in love with running after going out for cross country in the 8th grade. She was a 3-time Track State Champion at Duncan High School and 3-time All-Stater in Cross Country. Her family lost their home in the 1999 Oklahoma tornado outbreak. She went on to run for a year at the University of Tulsa, but injuries ultimately ended her collegiate career. She got back into competitive running as a road racer in her fifth year of college guided by her now husband and former elite distance runner, Conor Holt. As an undergrad, she began applying her science and research knowledge to help her stay healthy and run farther and faster.